Intramuscular Pharmacokinetics and Milk Levels of Ceftriaxone in Endometritic Cows

Kumar, S. 130 INTRODUCTION Ceftriaxone is effective in a variety of infections including meningitis, septicemia, pyoderma, colibacillosis, surgical prophylaxis and infections of the urinary tract, respiratory tract, wounds, soft tissues and joints (1). It is characterized by its excellent activity against Gram-negative pathogens including Salmonella, Shigella, Proteus, Klebsiella, Enterobacter, Pasteurella, Escherichia coli and Neisseria meningitidis. The relatively low Minimum Inhibitory Concentration (MIC) of ceftriaxone against Gram-negative bacteria makes it suitable for use in bacterial endometritis associated with Gramnegative pathogens, most of which are resistant to the other commonly used antibiotics (2). The use of antibacterial drugs that could penetrate into the udder parenchyma in therapeutic levels is of considerable importance, particularly in severe and life-threatening infectious conditions of the udder (3). There is meager information on the penetration of ceftriaxone from blood into milk. Although, some data are availIntramuscular Pharmacokinetics and Milk Levels of Ceftriaxone in Endometritic Cows